Phospho-creb
WebApr 13, 2011 · The phosphorylation-dependent transcription factor, cyclic AMP response element-binding protein (CREB), has been found to mediate PTEN regulation of multiple genes including Bcl-2 ( 10) and cyclin D2 ( 11 ). CREB activation promotes cell survival and phosphorylation at serine 133 is an indicator of CREB activation ( 12 ). WebCyclic AMP response element binding protein (CREB) is a basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in …
Phospho-creb
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WebMar 29, 2024 · The CREB binding domain, referred to as KIX, is α helical and binds to an unstructured kinase-inducible domain in CREB following phosphorylation of CREB at Ser-133. Phospho-Ser-133 forms direct contacts with residues in KIX, and these contacts are further stabilized by hydrophobic residues in the kinase-inducible domain which flank … WebUpon phosphorylation, CREB forms a functionally active dimer that binds the cis-acting CRE element within the promoters of target genes.220,221 Immediate-early genes, such as c-fos, Bcl-2, the IAPs, nNOS, and BDNF are important to neuronal survival and are gene targets of CREB. 221 Findings by Hardingham et al. 138 indicate that synaptic and …
CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene. WebAn immobilized capture antibody specific for CREB binds both phosphorylated and unphosphorylated CREB. After washing away unbound material, a biotinylated detection antibody is used to detect only phosphorylated receptor, utilizing a standard HRP format. Complete Your Research Human Phospho-CREB (S133) Antibody Cat # MAB6906R DNQX …
WebCAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene. [5] [6] This protein binds the cAMP response element, a DNA nucleotide sequence present in … WebProduct name Anti-CREB (phospho S133) antibody See all CREB primary antibodies Description Rabbit polyclonal to CREB (phospho S133) Host species Rabbit Tested applications Suitable for: WB, ICC/IF more details …
WebPhospho-CREB (Ser133) (87G3) Rabbit mAb detects endogenous levels of CREB only when phosphorylated at serine 133. The antibody also detects the phosphorylated form of the CREB-related protein, ATF-1. Species Reactivity: Human, Mouse, Rat. Species predicted to …
WebFeb 17, 2009 · To test whether any CREB potentiating compounds identified in the screen acted on PKA, compounds were tested in a PKA enzyme based assay that measured phosphorylation of a target peptide. 8-bromo-cAMP and 8-(4-chlorophenylthio)-cAMP, which are cAMP analogues, were found to be active in the primary CRE-β-lactamase screen, both … birmingham city council social careWebUse Anti-phospho-CREB (Ser133) Antibody (rabbit polyclonal antibody) is highly published and validated in EMSA, IHC,IHC(P), IP, WB to detect phospho-CREB (Ser133) also known … d and r furnitureWebPhospho-CREB (Ser133) Antibody (44-298G) in ICC/IF Immunofluorescent analysis of Phospho-CREB pSer133 Antibody was done on 70% confluent log phase A549 cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.25% Triton™ X-100 for 10 minutes, and blocked with 5% BSA for 1 hour at room temperature. birmingham city council smi discountWebThis product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility. - Improved sensitivity … d and r formsWebMar 24, 2024 · p-CREB-1 Antibody (10E9) is an IgG1 κ mouse monoclonal p-CREB-1 antibody (also designated p-CREB-1 antibody or CREB antibody) suitable for the detection of Ser 133 phosphorylated CREB-1 and Ser 63 phosphorylated ATF-1 of mouse, rat and human origin by WB and IP. p-CREB-1 Antibody (10E9) is available as the non-conjugated anti-p … birmingham city council smoking cessationWebTime-dependent induction of CREB phosphorylation in the hippocampus by the endogenous cannabinoid Masako Isokawa Department of Biological Sciences, The University of Texas at Brownsville, Brownsville TX 78520 Abstract The involvement of the endogenous cannabinoid system has been implicated in the rewarding actions of several drugs of abuse. d and r groceryWebUse Anti-phospho-CREB (Ser133) Antibody (rabbit polyclonal antibody) is highly published and validated in EMSA, IHC,IHC(P), IP, WB to detect phospho-CREB (Ser133) also known … d and r granite