Intratracheal administration in rats
WebPurpose. To evaluate the intratracheal route of administration as an alternative to oral administration for 2′,3′-dideoxyinosine (ddI). Methods. A ddI dose (40 mg/kg/300 µl or 6.5 mg/kg/50 µl) was instilled into the trachea in female Fisher rats and an intravenous tracer dose (9 µg/kg) of 3H-ddI was administered concomitantly to determine the drug … WebThe intratracheal administration of 50 mg (in 1 mL saline) of titanium carbide, boride, or nitride caused mild fibroses in the lungs of rats (Brahnova, 1969; Brahnova and …
Intratracheal administration in rats
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WebApr 11, 2024 · Just after gaseous anesthesia induction, pulmonary exposure of rats was performed by intratracheal administration using a suitable cannula of 200 μL in volume containing the plutonium citrate solution (administered activity = 2.6 or 2.8 kBq) or the plutonium nitrate solution (administered activity = 3.1, 5.0 or 11.9 kBq). WebDec 20, 2024 · We investigated the effects of intratracheal administration of autologous BMCs on MCT-induced pulmonary vessel remodeling and lung inflammation in rats. Methods All animal experiments were approved by the University of the Ryukyus Institutional Animal Care and Use Committee, and were performed in accordance with the National …
WebMar 27, 2024 · Based on these results, the system confirmed 100% administration of toxins to lung lesions in animals such as mice and rats, allowing quantitative administration directly through the airway. In this study, we evaluated the accuracy of the administration to intratracheal while using only one gender. WebAug 21, 2024 · The present study aimed to investigate the mechanism of DNA damage in rat lung and extra-pulmonary organs caused by TiO 2 nanoparticles. Methods: In the …
WebThe suspensions of Nano-TiO 2 were sonicated for 20 minutes and administrated to rats via one intratracheal injection at a dose of 0.6 mL/200 g body weight, respectively. 28 Rats … WebNiO nanoparticles were administered to rat lungs via intratracheal instillation or inhalation. During pulmonary toxicity caused by NiO nanoparticles, the induction of oxidative stress is a major factor. Both intratracheal instillation and inhalation of NiO nanoparticles induced pulmonary oxidative stress. The oxidative stress response protein, heme oxygenase-1 …
WebApr 8, 2024 · The intratracheal exposure consists at introducing the same solution directly into the trachea. The mouse is lying supine on a platform inclined at 45º, hanging stably …
WebJan 22, 2008 · After intratracheal administration of Man-7.5 and Man-5.0-liposomes in rats, a significantly high internalization and selective targeting to alveolar macrophages was observed. The enhanced cellular uptake in alveolar macrophages related to the mannose density of Man-liposomes was also confirmed both in vitro and in vivo confocal … cybersecurity top companiesWebJul 25, 2024 · 10.3791/61469-v. Dry powder formulations for inhalation have great potential in treating respiratory diseases. Before entering human studies, it is necessary to evaluate the efficacy of the dry powder formulation in preclinical studies. A simple and noninvasive method of the administration of dry powder in mice through the intratracheal route ... cheap storage near 1604 and culebraWebAfter establishing a pulmonary fibrosis model via the intratracheal administration of bleomycin (BLM) to 8-week-old mice, MSCs derived from human umbilical cords were administered intravenously or intratracheally on day 10 and the lungs were immunologically analyzed on days 14 and 21. cheap storage myrtle beach scWebThe suspensions of Nano-TiO 2 were sonicated for 20 minutes and administrated to rats via one intratracheal injection at a dose of 0.6 mL/200 g body weight, respectively. 28 Rats in the control group were instilled with 0.6 mL PBS per 200 g body-weight. Before injection, the rats were anesthetized by ether. Food and water were provided 2 hours ... cheap storage near matawan njWebMay 4, 2024 · studies have used intratracheal administration of stem cells and adeno-associated virus in newborn rats 10,11,12. However, a step-by-step presentation of the … cyber security topics for paperWeb1 day ago · Idiopathic pulmonary fibrosis (IPF) is the most widely studied interstitial lung disease. IPF eventually leads to respiratory insufficiency, lung canc… cyber security topics for blogWebIntratracheal delivery of 3 mumol/kg A-71623 in 50% ethanol to rats showed rapid and efficient absorption of drug from the lungs, with a Cmax of 2.7 microM and an AUC of 85 microM*min. Similar studies in dogs showed bioavailabilities of 59% and 46% for 2 and 3 mumol/kg intratracheal doses, respectively, relative to intravenous administration. cyber security topics for research