WebSoluble in water to >100 mM Form / State: Solid Overview Product name CB-1158 dihydrochloride (INCB01158) Description potent, selective human arginase I inhibitor Alternative names INCB0115 Biological description A potent nhibitor of arginase, with IC50s of 86 and 296 nM for recombinant human arginase 1 and 2, respectively. Purity >= 98% WebARG inhibitor INCB01158 was administered twice daily beginning from week 3 post MM induction. ( A ) Proliferation histograms. ( B ) Percentage of proliferating OT-I T cells in control (healthy C57BL/6 mice transferred with OT-I T cells and immunized with OVA protein) and MM-bearing mice treated were indicated with ARG inhibitor INCB01158.

Numidargistat Inhibitor TargetMol

WebCB-1158 (INCB01158) is an orally bioavailable, potent (IC50 = 98 nM), and selective (minimal off-target activity at 50000 nM) inhibitor of human arginase I, an immune-mediated anti … WebCB-1158 blocked myeloid cell-mediated suppression of T cell proliferation in vitro and reduced tumor growth in multiple mouse models of cancer, as a single agent and in combination with checkpoint blockade, adoptive T cell therapy, adoptive NK cell therapy, and the chemotherapy agent gemcitabine. incentive\u0027s hx

CB-1158 (INCB01158) Phase I Solid Tumor Data Presented at the …

WebCB-1158 (Numidargistat) (INCB01158) is an orally bioavailable, potent (IC50 = 98 nM), and selective (minimal off-target activity at 50000 nM) inhibitor of human arginase I, an … WebJun 5, 2024 · CB-1158 is an investigational immuno-oncology metabolic checkpoint inhibitor designed to target arginase, a critical immunosuppressive enzyme responsible for T-cell … WebNov 16, 2024 · INCB01158 has been previously demonstrated to exert antitumor effects in various tumor models 39. In Vκ*MYC model we observed a significant prolongation of … income from hp