Cisplatin mouse

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August undefined, 2024

WebAug 17, 2024 · Cisplatin (cis-Diaminodichloroplatinum, CDDP), one of the most potent chemotherapeutic agents, has been proven effective against various solid tumors, including sarcoma, soft tissue cancer, bone cancer, muscle cancer, and vascular cancer. WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in …

Cisplatin Mouse Models: Treatment, Toxicity and Translatability

Webstudies in mice and rats, cisplatin acted as a tumor initiator follow-ing transplacental exposure via a single intraperitoneal injection late in gestation. In mice, transplacental … WebAbstract Cisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... Thus, … population new mexico cities

Developing better mouse models to study cisplatin …

WebSep 1, 2024 · First, we examined whether cisplatin altered renal iron levels and induced oxidative stress in mice. Cisplatin increased the production of ferrous iron and hydroxyl radical, and they were colocalized in the kidney, suggesting the occurrence of the Fenton reaction ( Fig. 1 A–C). WebCisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by … WebDec 24, 2024 · In this approach, cisplatin treatment was started when primary tumors were palpable (200–300 mm 3 ). When primary tumors bearing legs reached 15–17 mm (Day 35), three mice from control and... population new plymouth

Differential damage and repair of DNA-adducts induced …

Exploring the Metabolic Differences between Cisplatin- and UV …

WebAug 28, 2024 · Three specific models using paclitaxel or cisplatin that stand out are 1) C57BL/6 female mice receiving paclitaxel and 2) CD1 male mice receiving paclitaxel and 3) C57BL/6 male mice receiving cisplatin. This overview may help scientists selecting suitable CIPN models for their research. WebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney … shark theoryWebOct 7, 2024 · Abstract 1. Introduction In 2024, 18.1 million new cases and 9.5 million cancer-related deaths were diagnosed worldwide. It is... 2. Cisplatin Mouse Models Cisplatin … population news 2022

"WebOur previous studies indicated that cisplatin administration to mice caused muscle atrophy. This is a concern for human patients receiving cisplatin. The insulin-like growth factor 1 (IGF-1)/phosphoinositide 3-kinase (PI3K)/Akt pathway stimulates the rate of protein synthesis in skeletal muscle. " - Cisplatin mouse

Cisplatin mouse

Wounding promotes ovarian cancer progression and decreases …

WebMar 16, 2024 · Cisplatin is an alkylating-like platinum-based chemotherapeutic drug commonly used in paediatric oncology [ 5 ]. The understanding of how exposure to cisplatin affects the future fertility of pre-pubertal boys predominantly comes from retrospective follow-up studies [ 6 ]. WebDec 2, 2024 · Cisplatin is a commonly used chemotherapeutic drug for cancer treatment, but its nephrotoxicity may lead to the deterioration of renal function. Previous work has been focused on cisplatin-induced acute …

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WebFeb 18, 2024 · C57BL/6 mice were intraperitoneally injected with cisplatin (15 mg/kg) and then sacrificed at 8, 12, 24, and 72 h. A The body weight decreased 8–72 h after cisplatin treatment ( n = 4). B... WebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine monophosphate …

WebJun 1, 2024 · Cisplatin (CP) nephrotoxicity is a severe renal complication in patients receiving CP-based chemotherapy, but the incidence of AKI following CP chemotherapy is not well defined in humans. Recent... WebAntitumor efficacy of aptamer‐siRNA nano‐zinc carriers in a mouse lung cancer model bearing A549/DDP cells. A549/DDP or A549 cells were implanted subcutaneously in nude mice. After 10 days, mice received a single intravenous injection of 5 mg/kg/d A10/NaZ/siUSP14#1 followed by serial fluorescence imaging at the indicated time points.

WebOct 1, 2024 · Developing better mouse models to study cisplatin-induced kidney injury Cisplatin-Induced AKI in the Clinical Setting. Although it is a potent choice for first-line … WebSep 1, 2024 · Cisplatin for injection can cause severe hypersensitivity reactions, including anaphylaxis and death. Manifestations have included facial edema, wheezing, …

WebCisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various side effects which limit its use....

WebAbstract Cisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... Thus, mice bearing A549/DDP cells were sacrificed and the organs were excised for ex vivo imaging. Ex vivo fluorescent imaging showed a strong signal in tumors, heart, liver, ... shark the youtubers real nameWebCisplatin-nephropathy model mice exhibited elevated levels of serum IS accompanied by elevated levels of blood urea nitrogen and serum creatinine. Furthermore, intraperitoneal administration of IS in mice promoted tumor growth and metastasis. Finally, we found that the MasR agonist Ang-(1-7) suppressed the IS-mediated effects on cell ... shark therapyWebCisplatin for injection is a highly emetogenic antineoplastic agent; premedicate with anti-emetic agents; without antiemetic therapy, marked nausea and vomiting occur in almost … shark theory mediaWebJul 4, 2024 · Cisplatin administered on the day of wounding decreased tumor burden by 50%, as compared to 90% in unwounded animals. Cisplatin on day 7 or day 28 decreased tumor burden by 80 and 37% respectively. Conclusions Surgical wounding increases ovarian tumor mass and decreases perioperative cisplatin efficacy in this animal model. shark the youtuber scaryWebCisplatin, a chemotherapy drug, is best known for curing testicular cancer. It is also used in the treatment of a wide range of other cancers, including lung, bladder, cervical, and ovarian cancers. Cisplatin and other similar … population news chinaWebDec 5, 2024 · Cisplatin also induces PD-L1 in tumor cells, suggesting dichotomous roles and supporting the need for combination with PD … population newspaper articlesWebOct 29, 2024 · The aim of this study was to investigate the underlying protective mechanisms of maltol on nephrotoxicity by cisplatin using a cisplatin-treated mouse model and a cellular toxicity model of HEK293 ... shark the youtuber song